ARF sees Pdgfrβ through the miR
نویسندگان
چکیده
Comment on: Iqbal N, et al. Cell Cycle 2014; 13:792–800; PMID:24401748; http://dx.doi.org/10.4161/cc.27725 Sara M Reed, Frederick W Quelle, and Dawn E Quelle*; Department of Pharmacology; The University of Iowa; Carver College of Medicine; Iowa City, IA USA; Medical Scientist Training Program; The University of Iowa; Carver College of Medicine; Iowa City, IA USA; Holden Comprehensive Cancer Center; The University of Iowa; Carver College of Medicine; Iowa City, IA USA; Department of Pathology; The University of Iowa; Carver College of Medicine; Iowa City, IA USA; *Email: [email protected]; http://dx.doi.org/10.4161/cc.28900
منابع مشابه
MicroRNA-182 prevents vascular smooth muscle cell dedifferentiation via FGF9/PDGFRβ signaling
The abnormal phenotypic transformation of vascular smooth muscle cells (SMCs) causes various proliferative vascular diseases. MicroRNAs (miRNAs or miRs) have been established to play important roles in SMC biology and phenotypic modulation. This study revealed that the expression of miR‑182 was markedly altered during rat vascular SMC phenotypic transformation in vitro. We aimed to investigate ...
متن کاملA microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma
Over-expression of PDGF receptors (PDGFRs) has been previously implicated in high-risk medulloblastoma (MB) pathogenesis. However, the exact biological functions of PDGFRα and PDGFRβ signaling in MB biology remain poorly understood. Here, we report the subgroup specific expression of PDGFRα and PDGFRβ and their associated biological pathways in MB tumors. c-MYC, a downstream target of PDGFRβ bu...
متن کاملOncomir miR-125b Suppresses p14ARF to Modulate p53-Dependent and p53-Independent Apoptosis in Prostate Cancer
MicroRNAs are a class of naturally occurring small non-coding RNAs that target protein-coding mRNAs at the post-transcriptional level and regulate complex patterns of gene expression. Our previous studies demonstrated that in human prostate cancer the miRNA miR-125b is highly expressed, leading to a negative regulation of some tumor suppressor genes. In this study, we further extend our studies...
متن کاملArf tumor suppressor and miR-205 regulate cell adhesion and formation of extraembryonic endoderm from pluripotent stem cells.
Induction of the Arf tumor suppressor (encoded by the alternate reading frame of the Cdkn2a locus) following oncogene activation engages a p53-dependent transcriptional program that limits the expansion of incipient cancer cells. Although the p19(Arf) protein is not detected in most tissues of fetal or young adult mice, it is physiologically expressed in the fetal yolk sac, a tissue derived fro...
متن کاملMicroRNA-146a inhibits glioma development by targeting Notch1.
Dysregulated epidermal growth factor receptor (EGFR) signaling through either genomic amplification or dominant-active mutation (EGFR(vIII)), in combination with the dual inactivation of INK4A/ARF and PTEN, is a leading cause of gliomagenesis. Our global expression analysis for microRNAs revealed that EGFR activation induces miR-146a expression, which is further potentiated by inactivation of P...
متن کامل